PHPT-3 |
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PHPT-3 was a study comparing a CD4 based antiretroviral monitoring and switching strategy with the standard viral load based monitoring strategy among immunocompromised antiretroviral naive adults receiving antiretroviral treatment in Thailand.
Due to the limited number of antiretroviral drugs belonging to few classes which share resistance mutations, toxicities, intolerance, the actual number of drug combinations available is restricted. This study addresses the following questions: • What is the most efficient strategy for the use of available antiretroviral drugs? • On which criteria should antiretroviral drug regimens be modified? 721 adult HIV infected patients were enrolled in 21 sites spread over Thailand. They had not received prior antiretroviral treatment and they were immunocompromised (CD4 count between 50 and 250 cells/mm3). |
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The analysis is based on the occurrence of clinical failures defined as confirmed CD4 below 50 cells/ml, new AIDS-defining event or death. Secondary analyses will take into account the number of drugs exhausted (taking into account cross-resistance mutations) and safety. The clinical follow up and statistical analysis are completed. Results have been published in 2013. (see link below)
Results were published in PLOS Medicine
For further information please refer to: ClinicalTrials.gov NCT00162682
Results were published in PLOS Medicine
For further information please refer to: ClinicalTrials.gov NCT00162682
