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Population pharmacokinetics of efavirenz in HIV-1 infected Thai children

This study aimed to develop a population pharmacokinetic model and describe efavirenz concentration-time courses in a large group of Thai children, and to predict exposures with current pediatric dosage recommendations. Efavirenz clearance was 35% lower in one third of patients, leading to higher efavirenz exposition. A high proportion of Thai children dosed according to the 2006 WHO guidelines achieved efavirenz through concentrations below the recommended minimum concentration. A significantly higher number of children with an efavirenz C24h below 1.0 mg/L had a viral load more than 400 copies/mL.
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For further information please refer to: 

• The 16th International Workshop on HIV Observational Databases (IWHOD 2012), March 29-31, 2012 in Athens, Greece [Homkham N, Urien S, Cressey TR, Theansavettrakul S, Nanta S, Buranabanjasatean S, Kamonpakorn N, Bunjongpak S, Saipanya A, Ingsrisawang L, Treluyer JM, Jourdain G. Efavirenz concentrations and HIV-1 viral load in HIV-1 infected Thai children receiving weight-based efavirenz dosing. 16th International Workshop on HIV Observational Databases (IWHOD 2012), March 29-31, 2012 in Athens, Greece. Poster.]
• The XIX International AIDS Conference (AIDS 2012), July 22-27, 2012 in Washington DC, USA [Homkham N, Urien S, Cressey TR, Techakunakorn P, Srirojana S, Puangsombat A, Hanpinitsak S, Na-Rajsima S, Ingsrisawang L, Treluyer JM, Jourdain G. Population pharmacokinetics of efavirenz in HIV-1-positive Thai children. XIX International AIDS Conference (AIDS 2012), July 22-27, 2012 in Washington DC, USA. Poster #TUPE059.]