High plasma efavirenz levels and hyperlipidemia in HIV-infected children
This study aimed to evaluate the association between hyperlipidemia and high plasma efavirenz levels in HIV-infected children. Children with high efavirenz concentrations were more likely to have high cholesterol but more likely to suppress viral replication. Before any dose reduction, the risk of viral breakthrough should be carefully considered.
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Homkham N, Akarathum N, Thanasiri P, Kwanchaipanich R, Hanpinitsak S, Karnchanamayul W, Traisathit P, Urien S, Ingsrisawang L, Ngo-Giang-Huong N, Lallemant M, Cressey T, Jourdain G. Association between Hyperlipidemia and High Plasma Efavirenz Levels in Children in the PHPT Observational Cohort, Thailand. 3rd International Workshop on HIV Pediatrics, July 15-16, 2011 in Rome, Italy. Poster.