Population pharmacokinetics of efavirenz in HIV-1 infected Thai children
This study aimed to develop a population pharmacokinetic model and describe efavirenz concentration-time courses in a large group of Thai children, and to predict exposures with current pediatric dosage recommendations. Efavirenz clearance was 35% lower in one third of patients, leading to higher efavirenz exposition. A high proportion of Thai children dosed according to the 2006 WHO guidelines achieved efavirenz through concentrations below the recommended minimum concentration. A significantly higher number of children with an efavirenz C24h below 1.0 mg/L had a viral load more than 400 copies/mL.
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