Timing and Risk factors of Mother to Child Transmission of HIV
Influence of mother and infant zidovudine treatment duration on the age at which HIV infection can be detected by polymerase chain reaction in infants.
The objective of this study was to investigate the influence of zidovudine (ZDV) prophylaxis duration in mothers and infants on the age at which infection becomes detectable by DNA PCR in non-breastfed infants. It was found that when mothers receive a short treatment, the proportion of infections detectable at birth is higher and the time at which infection becomes detectable after birth depends on the infant treatment duration.
For further information please refer to Influence of mother and infant zidovudine treatment duration on the age at which HIV infection can be detected by polymerase chain reaction in infants. [pubmed.org]
Risk factors for in utero or intrapartum mother-to-child transmission of human immunodeficiency virus type 1 in Thailand.
This objective of this study was the identification of risk factors for in utero and intrapartum transmission of HIV-1 which is crucial to the design and understanding of preventive interventions. It was conluded that with the exception of very high HIV-1 load, risk factors for in utero transmission were different from those for intrapartum transmission. Optimal prophylactic interventions must address each of the major risk factors, with appropriate timing.
Maternal HIV-1 DNA load and mother-to-child transmission.
This study sought to determin whether HIV-1 DNA-VL was independently associated with mother to child transmission of HIV in a population of women who received zidovudine prophylaxis during pregnancy and whose infants received zidovudine after birth. It was found that transmitting mothers had a significantly higher cell-associated HIV-1 DNA viral load than non transmitting mothers.
For further information please refer to Maternal HIV-1 DNA load and mother-to-child transmission.